renal cell carcinoma

Sorafenib (tosylate) tablets, film-coated 200 mg

Name Of The Medicine

NEXAVAR is a multikinase inhibitor targeting several serine/threonine and
receptor tyrosine kinases.

Sorafenib tosylate is
4-(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]-ureido}phenoxy)-N2-methylpyridine-2-carboxamide
4-methylbenzenesulfonate. The empirical formula is C₂₁H₁₆ClF₃N₄O₃
x C₇H₈O₃S and the CAS number is 28844-1-73-01
(sorafenib) and 475207-59-1 (sorafenib tosylate).

Sorafenib tosylate has the following structural formula:-

Description

Sorafenib tosylate is a white to yellowish or brownish solid with a
molecular weight of 637 g/mole. Sorafenib tosylate is practically insoluble in
aqueous media, slightly soluble in ethanol and soluble in PEG 400.

In addition to sorafenib tosylate, each NEXAVAR tablet contains the
following inactive ingredients: croscarmellose sodium, microcrystalline
cellulose, hypromellose, sodium lauryl sulphate, magnesium stearate, macrogol,
titanium dioxide, iron oxide red.